T. Denny Sanford, South Dakota
Sanford owns First Premier Bank, which helped him rack up a $2.5 billion net worth. Based in Sioux Falls, South Dakota, it is one of the largest issuers of Visa and Mastercards. He has given away more than $1.6 billion to charity in his lifetime.
Thomas Frist Jr., Tennessee
Frist's net worth is a whopping $11.7 billion thanks to his company HCA Healthcare. It operates hospitals and surgical centers in the U.S. and London. Though he no longer holds the executive position, his two sons are board members.
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